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Interaction information
Interaction summary
Short label
DCP1-RPL1A
Source database
BioGRID ID
Type
physical association (MI:0915)
Term ID
Name
physical association
Definition
Molecules that are experimentally shown to belong to the same functional or structural complex.
Is-a
1 item(s)
MI:0914
association
Date modified
2011-03-19 23:36:27 JST
Protein information
Short label
DCP1
Gene
DCP1 (Dcp1p)
GeneID
Official symbol
DCP1
Description
Dcp1p
Other names
1 designation(s)
Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p
Ontologies
13 ontology(s)
Functions
4 function(s)
GO:0003723
[IEA] RNA binding
Evidence
IEA Term ID
Name
RNA binding
Namespace
molecular_function
Definition
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Is-a
1 item(s)
GO:0003676
nucleic acid binding
GO:0003729
[IPI] mRNA binding
Evidence
IPI References
1 reference(s)
PubMed
DUNCKLEY, T, et al. , Genetics 2001 Jan;157(1):27-37
PMID
Title
Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.
Authors
DUNCKLEY, T, et al.
DUNCKLEY, T
TUCKER, M
PARKER, R
Citation
Genetics 2001 Jan;157(1):27-37
Term ID
Name
mRNA binding
Namespace
molecular_function
Definition
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA).
Is-a
1 item(s)
GO:0003723
RNA binding
GO:0008047
[IDA] enzyme activator activity
Evidence
IDA References
1 reference(s)
PubMed
SHE, Meipei, et al. , Nat. Struct. Mol. Biol. 2006 Jan;13(1):63-70
PMID
Title
Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.
Authors
SHE, Meipei, et al.
SHE, Meipei
DECKER, Carolyn J
CHEN, Nan
TUMATI, Suneeta
PARKER, Roy
SONG, Haiwei
Citation
Nat. Struct. Mol. Biol. 2006 Jan;13(1):63-70
Term ID
Name
enzyme activator activity
Namespace
molecular_function
Definition
Increases the activity of an enzyme.
Is-a
1 item(s)
GO:0030234
enzyme regulator activity
GO:0050072
[IDA] m7G(5')pppN diphosphatase activity
Evidence
IDA References
1 reference(s)
PubMed
SHE, Meipei, et al. , Nat. Struct. Mol. Biol. 2006 Jan;13(1):63-70
PMID
Title
Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.
Authors
SHE, Meipei, et al.
SHE, Meipei
DECKER, Carolyn J
CHEN, Nan
TUMATI, Suneeta
PARKER, Roy
SONG, Haiwei
Citation
Nat. Struct. Mol. Biol. 2006 Jan;13(1):63-70
Term ID
Name
m7G(5')pppN diphosphatase activity
Namespace
molecular_function
Definition
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
Synonyms
4 synonym(s)
7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity (EC:3.6.1.30)
decapase activity (EC:3.6.1.30)
M(7)G(5')pppN pyrophosphatase activity
m7G(5')pppN pyrophosphatase activity (EC:3.6.1.30)
Is-a
1 item(s)
GO:0016462
pyrophosphatase activity
Processes
5 process(s)
GO:0000184
[IEA] nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Evidence
IEA Term ID
Name
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Namespace
biological_process
Definition
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Synonyms
6 synonym(s)
mRNA breakdown, nonsense-mediated decay
mRNA catabolic process, nonsense-mediated
mRNA catabolism, nonsense-mediated
mRNA degradation, nonsense-mediated decay
nonsense-mediated mRNA decay
nuclear mRNA catabolic process, nonsense-mediated decay
Is-a
1 item(s)
GO:0000956
nuclear-transcribed mRNA catabolic process
GO:0000290
[IDA] deadenylation-dependent decapping of nuclear-transcribed mRNA
Evidence
IDA References
1 reference(s)
PubMed
DUNCKLEY, T, et al. , Genetics 2001 Jan;157(1):27-37
PMID
Title
Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.
Authors
DUNCKLEY, T, et al.
DUNCKLEY, T
TUCKER, M
PARKER, R
Citation
Genetics 2001 Jan;157(1):27-37
Term ID
Name
deadenylation-dependent decapping of nuclear-transcribed mRNA
Namespace
biological_process
Definition
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
Synonyms
2 synonym(s)
deadenylation-dependent decapping of nuclear mRNA
deadenylylation-dependent decapping
Is-a
1 item(s)
GO:0000956
nuclear-transcribed mRNA catabolic process
GO:0006397
[IEA] mRNA processing
Evidence
IEA Term ID
Name
mRNA processing
Namespace
biological_process
Definition
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
Synonyms
1 synonym(s)
Is-a
2 item(s)
GO:0006396
RNA processing
GO:0016071
mRNA metabolic process
GO:0006399
[RCA] tRNA metabolic process
Evidence
RCA Term ID
Name
tRNA metabolic process
Namespace
biological_process
Definition
The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Synonyms
1 synonym(s)
Is-a
1 item(s)
GO:0034660
ncRNA metabolic process
GO:0006401
[RCA] RNA catabolic process
Evidence
RCA Term ID
Name
RNA catabolic process
Namespace
biological_process
Definition
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Synonyms
3 synonym(s)
RNA breakdown
RNA catabolism
RNA degradation
Is-a
2 item(s)
GO:0016070
RNA metabolic process
GO:0044265
cellular macromolecule catabolic process
Components
4 component(s)
GO:0000932
[IDA] cytoplasmic mRNA processing body
Evidence
IDA References
1 reference(s)
PubMed
SHETH, Ujwal, et al. , Science 2003 May;300(5620):805-8
PMID
Title
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.
Authors
SHETH, Ujwal, et al.
Citation
Science 2003 May;300(5620):805-8
Term ID
Name
cytoplasmic mRNA processing body
Namespace
cellular_component
Definition
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.
Synonyms
3 synonym(s)
cytoplasmic foci
P body
P-body
Is-a
2 item(s)
GO:0030529
ribonucleoprotein complex
GO:0044444
cytoplasmic part
GO:0000932
[IEA] cytoplasmic mRNA processing body
Evidence
IEA Term ID
Name
cytoplasmic mRNA processing body
Namespace
cellular_component
Definition
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.
Synonyms
3 synonym(s)
cytoplasmic foci
P body
P-body
Is-a
2 item(s)
GO:0030529
ribonucleoprotein complex
GO:0044444
cytoplasmic part
GO:0000932
[IMP] cytoplasmic mRNA processing body
Evidence
IMP References
1 reference(s)
PubMed
SHETH, Ujwal, et al. , Science 2003 May;300(5620):805-8
PMID
Title
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.
Authors
SHETH, Ujwal, et al.
Citation
Science 2003 May;300(5620):805-8
Term ID
Name
cytoplasmic mRNA processing body
Namespace
cellular_component
Definition
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.
Synonyms
3 synonym(s)
cytoplasmic foci
P body
P-body
Is-a
2 item(s)
GO:0030529
ribonucleoprotein complex
GO:0044444
cytoplasmic part
GO:0005737
[IEA] cytoplasm
Evidence
IEA Term ID
Name
cytoplasm
Namespace
cellular_component
Definition
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Is-a
1 item(s)
GO:0044424
intracellular part
Origin
Saccharomyces cerevisiae S288c
NCBI Taxonomy ID
Name
Saccharomyces cerevisiae S288c
Cross references
9 item(s)
RefSeq
Entrez Gene
SGD
UniProt
BioGRID
GenBank Nucleotide
GenBank Protein
GenBank Protein
GenBank Protein
Experimental roles
1 role(s)
Role 1
bait
Term ID
Name
bait
Definition
Molecule experimentally treated to capture its interacting partners.
Is-a
1 item(s)
MI:0495
experimental role
Identification methods
1 identification method(s)
Method 1
predetermined participant
Term ID
Name
predetermined participant
Definition
Molecule whose sequence identity is not checked and has been assumed from external or previous experimental evidence(s).
Synonyms
1 synonym(s)
predetermined (PSI-MI-short)
Is-a
1 item(s)
MI:0661
experimental participant identification
RNA information
Short label
RPL1A
Gene
RPL1A (L1A)
GeneID
Official symbol
RPL1A
Synonyms
1 synonym(s)
Description
L1A
Other names
1 designation(s)
Ontologies
12 ontology(s)
Functions
3 function(s)
GO:0003723
[IEA] RNA binding
Evidence
IEA Term ID
Name
RNA binding
Namespace
molecular_function
Definition
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Is-a
1 item(s)
GO:0003676
nucleic acid binding
GO:0003735
[IEA] structural constituent of ribosome
Evidence
IEA Term ID
Name
structural constituent of ribosome
Namespace
molecular_function
Definition
The action of a molecule that contributes to the structural integrity of the ribosome.
Synonyms
2 synonym(s)
ribosomal protein
ribosomal RNA
Is-a
1 item(s)
GO:0005198
structural molecule activity
GO:0003735
[TAS] structural constituent of ribosome
Evidence
TAS References
1 reference(s)
PubMed
PLANTA, R J, et al. , Yeast 1998 Mar;14(5):471-7
PMID
Title
The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.
Authors
PLANTA, R J, et al.
Citation
Yeast 1998 Mar;14(5):471-7
Term ID
Name
structural constituent of ribosome
Namespace
molecular_function
Definition
The action of a molecule that contributes to the structural integrity of the ribosome.
Synonyms
2 synonym(s)
ribosomal protein
ribosomal RNA
Is-a
1 item(s)
GO:0005198
structural molecule activity
Processes
4 process(s)
GO:0006396
[IEA] RNA processing
Evidence
IEA Term ID
Name
RNA processing
Namespace
biological_process
Definition
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
Is-a
1 item(s)
GO:0016070
RNA metabolic process
GO:0006412
[IEA] translation
Evidence
IEA Term ID
Name
translation
Namespace
biological_process
Definition
The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.
Synonyms
6 synonym(s)
protein anabolism
protein biosynthesis
protein biosynthetic process (GOC:curators)
protein formation
protein synthesis
protein translation
Is-a
2 item(s)
GO:0034645
cellular macromolecule biosynthetic process
GO:0044267
cellular protein metabolic process
GO:0006412
[TAS] translation
Evidence
TAS References
1 reference(s)
PubMed
PLANTA, R J, et al. , Yeast 1998 Mar;14(5):471-7
PMID
Title
The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.
Authors
PLANTA, R J, et al.
Citation
Yeast 1998 Mar;14(5):471-7
Term ID
Name
translation
Namespace
biological_process
Definition
The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.
Synonyms
6 synonym(s)
protein anabolism
protein biosynthesis
protein biosynthetic process (GOC:curators)
protein formation
protein synthesis
protein translation
Is-a
2 item(s)
GO:0034645
cellular macromolecule biosynthetic process
GO:0044267
cellular protein metabolic process
GO:0006417
[RCA] regulation of translation
Evidence
RCA Term ID
Name
regulation of translation
Namespace
biological_process
Definition
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
Synonyms
4 synonym(s)
regulation of protein anabolism
regulation of protein biosynthesis
regulation of protein formation
regulation of protein synthesis
Is-a
4 item(s)
GO:0010556
regulation of macromolecule biosynthetic process
GO:0010608
posttranscriptional regulation of gene expression
GO:0031326
regulation of cellular biosynthetic process
GO:0032268
regulation of cellular protein metabolic process
Components
5 component(s)
GO:0005622
[IEA] intracellular
Evidence
IEA Term ID
Name
intracellular
Namespace
cellular_component
Definition
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Synonyms
4 synonym(s)
internal to cell
nucleocytoplasm (GOC:mah)
protoplasm
protoplast (GOC:mah)
Is-a
1 item(s)
GO:0044464
cell part
GO:0005737
[IEA] cytoplasm
Evidence
IEA Term ID
Name
cytoplasm
Namespace
cellular_component
Definition
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Is-a
1 item(s)
GO:0044424
intracellular part
GO:0005840
[IEA] ribosome
Evidence
IEA Term ID
Name
ribosome
Namespace
cellular_component
Definition
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Synonyms
1 synonym(s)
Is-a
3 item(s)
GO:0030529
ribonucleoprotein complex
GO:0043232
intracellular non-membrane-bounded organelle
GO:0044444
cytoplasmic part
GO:0022625
[TAS] cytosolic large ribosomal subunit
Evidence
TAS References
1 reference(s)
PubMed
PLANTA, R J, et al. , Yeast 1998 Mar;14(5):471-7
PMID
Title
The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.
Authors
PLANTA, R J, et al.
Citation
Yeast 1998 Mar;14(5):471-7
Term ID
Name
cytosolic large ribosomal subunit
Namespace
cellular_component
Definition
The large subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. Examples of this component are found in Mus musculus, and in Bacterial and Archaeal species.
Synonyms
4 synonym(s)
50S ribosomal subunit
60S ribosomal subunit
eukaryotic ribosomal LSU
prokaryotic large ribosomal subunit
Is-a
2 item(s)
GO:0015934
large ribosomal subunit
GO:0044445
cytosolic part
GO:0030529
[IEA] ribonucleoprotein complex
Evidence
IEA Term ID
Name
ribonucleoprotein complex
Namespace
cellular_component
Definition
A macromolecular complex containing both protein and RNA molecules.
Synonyms
4 synonym(s)
protein-RNA complex
ribonucleoprotein
RNA-protein complex
RNP
Is-a
2 item(s)
GO:0032991
macromolecular complex
GO:0044424
intracellular part
Origin
Saccharomyces cerevisiae S288c
NCBI Taxonomy ID
Name
Saccharomyces cerevisiae S288c
Cross references
11 item(s)
RefSeq
Entrez Gene
SGD
UniProt
BioGRID
GenBank Nucleotide
GenBank Protein
GenBank Protein
GenBank Protein
GenBank Protein
GenBank Protein
Experimental roles
1 role(s)
Role 1
prey
Term ID
Name
prey
Definition
Molecule experimentally identified as being captured by a given bait.
Is-a
1 item(s)
MI:0495
experimental role
Identification methods
1 identification method(s)
Method 1
predetermined participant
Term ID
Name
predetermined participant
Definition
Molecule whose sequence identity is not checked and has been assumed from external or previous experimental evidence(s).
Synonyms
1 synonym(s)
predetermined (PSI-MI-short)
Is-a
1 item(s)
MI:0661
experimental participant identification
Experiments (1)
Experiment 1
Tharun S (2001)
Full name
Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.
Detection method
affinity chromatography technology (MI:0004)
Term ID
Name
affinity chromatography technology
Definition
This class of approaches is characterised by the use of affinity resins as tools to purify molecule of interest (baits) and their binding partners. The baits can be captured by a variety of high affinity ligands linked to a resin - for example, antibodies specific for the bait itself, antibodies for specific tags engineered to be expressed as part of the bait or other high affinity binders such as glutathione resins for GST fusion proteins, metal resins for histidine-tagged proteins.
Synonyms
2 synonym(s)
affinity chrom (PSI-MI-short)
Affinity purification (PSI-MI-alternate)
Is-a
2 item(s)
MI:0091
chromatography technology
MI:0400
affinity technology
Host organisms
1 host organism(s)
Origin
unidentified
NCBI Taxonomy ID
Name
unidentified
Synonyms
11 synonym(s).
miscellaneous nucleic acid
none
not shown
not specified
other
sonstige nucleic acid
unidentified organism
unknown
unknown organism
unknwon
unspecified
Reference
THARUN, S, et al. , Mol. Cell 2001 Nov;8(5):1075-83
PMID
Title
Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.
Authors
THARUN, S, et al.
Citation
Mol. Cell 2001 Nov;8(5):1075-83
References (1)
Reference 1
THARUN, S, et al. , Mol. Cell 2001 Nov;8(5):1075-83
PMID
Title
Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.
Authors
THARUN, S, et al.
Citation
Mol. Cell 2001 Nov;8(5):1075-83
Attributes (2)
Attributes
2 attribute(s)
comment
Imported from BioGRID, BIOGRID: All Interactions for Build 3.1.74, release 3.1.74, release date 2011-02-25.
BioGRID Evidence Code
Affinity Capture-RNA
144860
MI:0915
854016
GO:0003723
11139489
559292
NP_014492
S000005509
Q12517
296147858